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STING agonist-1

CAS No. 702662-50-8

STING agonist-1( G10 )

Catalog No. M21625 CAS No. 702662-50-8

STING agonist-1 is a human-specific STING agonistelicits antiviral activity against emerging Alphaviruses.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    STING agonist-1
  • Note
    Research use only, not for human use.
  • Brief Description
    STING agonist-1 is a human-specific STING agonistelicits antiviral activity against emerging Alphaviruses.?
  • Description
    STING agonist-1 is a human-specific STING agonistelicits antiviral activity against emerging Alphaviruses.?
  • In Vitro
    G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts.G10 is an indirect activator of human STING-dependent phenotypes.G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling.STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity.G10 induces STING-dependent synthesis and secretion of bioactive interferon.G10 induces innate antiviral mRNA expression in primary human cells.
  • In Vivo
    ——
  • Synonyms
    G10
  • Pathway
    Immunology/Inflammation
  • Target
    STING
  • Recptor
    STING
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    702662-50-8
  • Formula Weight
    430.88
  • Molecular Formula
    C21H16ClFN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (232.08 mM; Need ultrasonic)
  • SMILES
    Fc1cccc(Cl)c1CN1C(=O)CSc2ccc(cc12)C(=O)NCc1ccco1
  • Chemical Name
    4-(2-Chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-34-dihydro-2H-benzo[b][14]thiazine-6-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sali TM et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324.
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